Friday, May 21, 2010

Scientists create synthetic cell, version 1.0

This is very, very, interesting and has many implications.
- LRK -
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http://www.jcvi.org/cms/press/press-releases/full-text/article/first-self-replicating-synthetic-bacterial-cell-constructed-by-j-craig-venter-institute-researcher/
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As in the team’s 2008 publication in which they described the successful synthesis of the M. genitalium genome, they designed and inserted into the genome what they called watermarks. These are specifically designed segments of DNA that use the “alphabet” of genes and proteins that enable the researcher to spell out words and phrases. The watermarks are an essential means to prove that the genome is synthetic and not native, and to identify the laboratory of origin. Encoded in the watermarks is a new DNA code for writing words, sentences and numbers. In addition to the new code there is a web address to send emails to if you can successfully decode the new code, the names of 46 authors and other key contributors and three quotations: "TO LIVE, TO ERR, TO FALL, TO TRIUMPH, TO RECREATE LIFE OUT OF LIFE." - JAMES JOYCE; "SEE THINGS NOT AS THEY ARE, BUT AS THEY MIGHT BE.”-A quote from the book, “American Prometheus”; "WHAT I CANNOT BUILD, I CANNOT UNDERSTAND." - RICHARD FEYNMAN.
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Check this out and stand by for more advances.
- LRK -

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May 20, 2010 3:12 PM PDT
Scientists create synthetic cell, version 1.0
 by Tim Hornyak

Scientists at the J. Craig Venter Institute have created a synthetic cell that can survive and reproduce itself according to an artificial DNA sequence, promising designer genomes with which researchers can produce sophisticated artificial organisms.

The new bacterial cell, "Mycoplasma mycoides JCVI-syn1.0," is the result of a 15-year, $30 million effort by genetics pioneer Craig Venter. The study, led by the institute's Dan Gibson, is reported in the May 21 edition of the journal Science.

The team of 25 researchers took Mycoplasma capricolum bacteria and completely rewrote its genetic code of more than 1 million base pairs of DNA. The data was sequenced as chemical DNA fragments and sewn together using yeast and E. coli bacteria.

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Read a lot more at the links.
- LRK -

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http://singularityhub.com/2010/05/20/venter-creates-first-synthetic-self-replicating-bacteria-from-scratch/#more-16798
Singularity Hub - The Future Is Here Today...Robots, Genetics, AI, Longevity, Singularity

Venter Creates First Synthetic Self-Replicating Bacteria from Scratch May 20th, 2010 by Aaron Saenz

Craig Venter wants to program life the way we program computers, and today he announced a momentous win: the first synthetic self-replicating bacterium. The J. Craig Venter Institute (JCVI) used the four types of chemicals that make up DNA, and complex assembly methods utilizing yeast cells, to ’program’ the 1.08 million base pairs that make up the genome for the bacteria cell. As described in the journal Science, the result was a synthetic copy of the Mycoplasma mycoides, dubbed M. mycoides JCVI-syn1.0, that can grow and divide like normal. The little “1.0″ highlights the vast potential of Venter’s project, as JCVI will be able to update and improve their synthetic organism base pair by base pair, gene by gene. Computers can now program sustainable synthetic life – welcome to the future.

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[See Video, links and more - LRK -].
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View the videos if you can.  Good talk.
- LRK -

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http://singularityhub.com/2010/02/08/venters-successes-in-creating-synthetic-life-video/
Singularity Hub - The Future Is Here Today...Robots, Genetics, AI,
Longevity, Singularity

Venter’s Successes in Creating Synthetic Life (video)
February 8th, 2010 by Aaron Saenz

Craig Venter is pushing the boundaries of what humans can do with DNA and aims to create new life to serve our needs. At TEDMED this past year, he discussed what he and his company, Synthetic Genomics, have accomplished by analyzing and manipulating the genes of simple organisms. While the presentation was titled “What could we do with synthetic life?” it would have been more apt to call it “What we have done so far is going to blow your freakin’ mind.” Venter gives an in depth look at the methods which will lead to custom  made organisms.  Biofuel, new antibiotics, vaccines – Venter could one day make them all by using yeast and bacteria to reproduce artificially constructed genomes. As many have said, synthetic biology is likely to be the defining technology of the 21st century, and Venter plans on helping to write that definition. Check out his TEDMED video, in its entirety, after the break.

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[screen capture and video credit: TEDMED]

[The TEDMED video - 18 minute - and a time line guide provided by Aaron Saenz. ]
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Some of the crew and much more at JVCI.
- LRK -

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http://www.jcvi.org/cms/research/projects/first-self-replicating-synthetic-bacterial-cell/photos/
First Self-Replicating Synthetic Bacterial Cell
Photos

http://www.jcvi.org/cms/research/projects/first-self-replicating-synthetic-bacterial-cell/overview/
Overview

Genomic science has greatly enhanced our understanding of the biological world. It is enabling researchers to "read" the genetic code of organisms from all branches of life by sequencing the four letters that make up DNA. Sequencing genomes has now become routine, giving rise to thousands of genomes in the public  databases. In essence, scientists are digitizing biology by converting the A, C, T, and G's of the chemical makeup of DNA into 1's and 0's in a computer.  But can one reverse the process and start with 1's and 0's in a computer to define the characteristics of a living cell? We set out to answer this question.
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http://www.jcvi.org/cms/research/projects/first-self-replicating-synthetic-bacterial-cell/video/
May 20, 2010 Press Conference
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[Don't miss this press release  and the questions that are part of it. - LRK -]
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Thanks for looking up with me.
- LRK -
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WHAT THE MIND CAN CONCEIVE, AND BELIEVE, IT WILL ACHIEVE - LRK

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